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BETA GLOBIN GENE HAPLOTYPES IN BAHRAIN PATIENTS WITH SICKLE CELL ANAEMIA

 
 

الزيارات : 73

التاريخ : 26-10-2009

 
 

عن الملف : DOWNLOAD THE FULL ABSTRUCT

المرفقات : beta_globin_abstract[1].pdf

 
 

Molecular genetic studies were undertaken to determine the haplotype of chromosomes carrying the sickle cell allele in Bahrain patients, and hence allow consideration of the possible source of these alleles.  A total of 59 individuals form 19 families were studied.  Of these 35 were affected with sickle cell anaemia, and 24 were carriers.

 

Haplotypes were investigated by PCR amplification of globin target sequences followed by restriction digestion using HindIII, AvaII, HindII, and HinfI polymorphism.

 

In the 19 families the Bs gene was found to be linked to the haplotype + + + + +- (also known as the Asian haplotype) in 33 chromosomes (90%), to the haplotype +-+-++ known as the S2 haplotype in 2 chromosome (5%), to haplotype S1 (-++++) in one chromosome (2.5%), and to the haplotype - - + - - + found in association with beta thalassaemia in one family (2.5%).

 
     
 

الارشيف

العنوان التاريخ الزيارات
 

ABO Blood Group and RhD Phenotypes in Bahrain: Results of Screening

26-10-2009 83
 

BETA GLOBIN GENE HAPLOTYPES IN BAHRAIN PATIENTS WITH SICKLE CELL ANAEMIA

26-10-2009 73
 

Features of sickle-cell disease in Bahrain

23-01-2012 111
 

Review of the spectrum of genetic diseases in Bahrain

23-01-2012 119
 

Clients' Satisfaction of the Premarital Counseling Service in Bahrain

22-10-2009 111
 

Knowledge, attitude, and practice of reproductive behavior in Iranian minor thalassemia couples

11-08-2009 247
 

طبيعة فقر الدم المنجلي لدى البحرينيينTHE NATURE OF SICKLE CELL DISEASE IN BAHRAIN

27-10-2009 85
 

التكيس الليفي في البحرين Incidence of cystic fibrosis in Bahrain

27-10-2009 77
 

Spectrum of b thalassemia Mutation in Bahrain

23-09-2007 71
 

Incidence of genetic disorders of haemoglobins in the hospital population of Bahrain

23-09-2007 191

الصفحات :1-2-3-4