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BETA GLOBIN GENE HAPLOTYPES IN BAHRAIN PATIENTS WITH SICKLE CELL ANAEMIA

 
 

الزيارات : 296

التاريخ : 26-10-2009

 
 

عن الملف : DOWNLOAD THE FULL ABSTRUCT

المرفقات : beta_globin_abstract[1].pdf

 
 

Molecular genetic studies were undertaken to determine the haplotype of chromosomes carrying the sickle cell allele in Bahrain patients, and hence allow consideration of the possible source of these alleles.  A total of 59 individuals form 19 families were studied.  Of these 35 were affected with sickle cell anaemia, and 24 were carriers.

 

Haplotypes were investigated by PCR amplification of globin target sequences followed by restriction digestion using HindIII, AvaII, HindII, and HinfI polymorphism.

 

In the 19 families the Bs gene was found to be linked to the haplotype + + + + +- (also known as the Asian haplotype) in 33 chromosomes (90%), to the haplotype +-+-++ known as the S2 haplotype in 2 chromosome (5%), to haplotype S1 (-++++) in one chromosome (2.5%), and to the haplotype - - + - - + found in association with beta thalassaemia in one family (2.5%).

 
     
 

الارشيف

العنوان التاريخ الزيارات
 

ABO Blood Group and RhD Phenotypes in Bahrain: Results of Screening

26-10-2009 307
 

BETA GLOBIN GENE HAPLOTYPES IN BAHRAIN PATIENTS WITH SICKLE CELL ANAEMIA

26-10-2009 296
 

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Review of the spectrum of genetic diseases in Bahrain

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Clients' Satisfaction of the Premarital Counseling Service in Bahrain

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Knowledge, attitude, and practice of reproductive behavior in Iranian minor thalassemia couples

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طبيعة فقر الدم المنجلي لدى البحرينيينTHE NATURE OF SICKLE CELL DISEASE IN BAHRAIN

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27-10-2009 332
 

Spectrum of b thalassemia Mutation in Bahrain

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Incidence of genetic disorders of haemoglobins in the hospital population of Bahrain

23-09-2007 555

الصفحات :1-2-3-4