• contact

يقدم الموقع بعص النصائح ووجهات النظر المختلفه من خلال بعض المقالات

 
 

Children with sickle cell anemia with normal TCD and without silent infarcts have a low incidence of new strokes

 
 

الزيارات : 104

التاريخ : 03-04-2018

 
 

عن الملف :

المرفقات : لا يوجد

 
 


 American Journal of Hematology Volume 0, Issue 0

Research Article

Children with sickle cell anemia with normal TCD and without silent infarcts have a low incidence of new strokes

Lori C. Jordan MD, PhD 

 ... See all authors 

First published: 9 March 2018

https://doi.org/10.1002/ajh.25085


About

 

Abstract

In a prospective cohort study, we tested the hypothesis that children with sickle cell anemia (SCA) with normal transcranial Doppler ultrasound (TCD) velocities and without silent cerebral infarcts (SCIs) would have a lower incidence rate of new neurological events (strokes, seizures or transient ischemic attacks) compared to children with normal TCD measurements and SCIs, not receiving regular blood transfusions.

Non‐randomized participants from the Silent Cerebral Infarct Transfusion (SIT) Trial who had screening magnetic resonance imaging (MRI) of the brain and normal TCD measurements were included. Follow‐up ended at the time of first neurological event, start of regular blood transfusion, or loss to follow‐up, whichever came first. The primary endpoint was a new neurological event.

Of 421 participants included, 68 had suspected SCIs. Mean follow‐up was 3.6 years. Incidence rates of new neurological events in non‐transfused participants with normal TCD values with SCIs and without SCIs were 1.71 and 0.47 neurological events per 100 patient‐years, respectively, p=0.065. The absence of SCI(s) at baseline was associated with a decreased risk of a new neurological event (hazard ratio 0.231, 95% CI 0.062 – 0.858; p=0.029). Local pediatric neurologists examined 67 of 68 participants with suspected SCIs and identified 2 with overt strokes classified as SCIs by local hematologists; subsequently one had a seizure and the other an ischemic stroke. Children with SCA, without SCIs, and normal TCD measurements have a significantly lower rate of new neurological events when compared to those with SCIs and normal TCD measurements. Pediatric neurology assessment may assist risk stratification. This article is protected by copyright. All rights reserved.

Supporting Information

About Wiley Online Library

Help & Support

Opportunities

Connect with Wiley

Copyright © 1999-2018 John Wiley & Sons, Inc. All rights reserved

 
 
     
 

الارشيف

العنوان التاريخ الزيارات
 

Children with sickle cell anemia with normal TCD and without silent infarcts have a low incidence of new strokes

03-04-2018 104
 

Over 95 Patients Enrolled in Sickle Cell Study

12-11-2017 267
 

The International Conference on Sickle Cell Disease: Management and Prevention

16-06-2013 440
 

Hospital staff perceptions of SCD patients pain

01-02-2018 309
 

Painkiller addiction and pseudoaddiction in SCD

06-06-2013 331
 

SCD patients experiences of hospital pain management

06-06-2013 315
 

نقل و زراعة الخلايا الجذعية

27-05-2013 750
 

أطفال الأنابيب لعلاج أمراض الدم الوراثية

27-05-2013 399
 

الثلاسيميا.. لا يعدو كونه مرضاً

07-10-2011 338
 

زواج الأقارب

03-02-2007 324

الصفحات :1-2