• contact

هنك أبحاث كثيرة كتبت في هذا الموضوع، سنحاول هنا وضع بعضها.للاستفسار يرجى الاتصال على العنوان التالي:

info@bnhas.org

 

 
 

Prevalence of Abnormal Hemoglobins among Students in Bahrain: A Ten-Year Study

 
 

Date   :  09-03-2011

Visits  : 61  
 

Attachments : لا يوجد

Descripiton :

 
 

Bahrain Medical Bulletin, Vol. 33, No. 1, March 2011

Prevalence of Abnormal Hemoglobins among Students in Bahrain: A Ten-Year Study

click the link below for full research

http://www.bahrainmedicalbulletin.com/march_2011/Abnormal_Hb-Students.pdf

 

 

Shaikha Salim Al Arrayed, MB, ChB, DHCG, PhD*

Background: Sickle cell disease (SCD) and thalassemia are common in the Arab countries.

Objective: The aim of this study is to evaluate the prevalence of abnormal hemoglobin in secondary school students in Bahrain and to compare the prevalence rates from 1999-2008.

Design: Prospective study.

Setting: Hematology Laboratory at Salmaniya Medical Complex.

Method: The students of the 11th grade (2nd grade in secondary schools), during 1999-2008 were screened. Hb Chromatography was done by HPLC. Informed consents were obtained from the parents.

Result: Sixty thousand and four hundred twenty-four (60,424) students were screened. The most common type of hemoglobin was hemoglobin A, found in 50756 (84%) of the students. The second was Hb S, the average prevalence of SCD was 1.13%, sickle cell trait was seen (SCT) in 13.3%. SCT in 1999 was 13.81 and in 2008 it was 12.8.

Hb D heterozygous was found in 306 (0.51%) of the screened individuals. Hb D homozygous was found in 17 (0.03%). Hb EA heterozygous was found in 84 (0.14%), while Hb E homozygous was found in 3 (0.005%) of the students.

Conclusion: The prevalence of SCD among the age groups (16-18 years) revealed a significant decline during these ten years period P= .000. The continuation of the screening and education efforts might reduce the prevalence further, if not eliminate it. SCD in 2000 was 1.3 and in 2008 it was 0.81.

Bahrain Med Bull 2011; 33(1):

 

Falciparum malaria was endemic in Bahrain until 1970, but great efforts by the government to eliminate it proved to be eventually successful. The malaria associated genetic defects of red cells, such as SCD, thalassemia and glucose 6-phosphate dehydrogenase deficiency (G6PD), were expected to be common1-4.

________________________________________________________________________

 

* Clinical Geneticist

Genetic Department

Salmaniya Medical Complex

Kingdom of Bahrain

E-mail: ssarayed@batelco.com.bh

The newborn screening study conducted in Bahrain during 1984-1985 revealed 2.1% prevalence rate of SCD. According to the statistics, 200 babies born every year suffered from SCD, with 11.2% being carriers of the abnormal gene for SCD, and 20% have G6PD deficiency. The carrier status for beta thalassemia was 2-4% in a premarital counseling study conducted in 19942-5.

The aim of the study was to determine the prevalence of common genetic blood disorders (thalassemia and sickle cell anemia) among students.

METHOD

 

This is a cross sectional interval study, performed annually for a period of ten years. Nearly six thousand students were screened each year for thalassemia and sickle cell anemia. Sixty thousand and four hundred twenty-four (60,424) students were screened.

Informed consent was taken from the parents of children under 18 years of age and those over the age of 18 years were given the choice. The test was applicable for all students of the 11th grade. The results were kept confidential between the researcher's team, the student and his family.

Personal characteristics were documented. Each student received a card with the result which could be maintained throughout life. The schools received reports about the prevalence of these diseases in their school.

The obtained data were coded, processed and analyzed by SPSS.

RESULT

 

Sixty thousand and four hundred twenty-four (60,424) students were screened. About 85% of the parents granted permission to test their children. The numbers of students screened yearly during 1999-2008 were 5685, 5694, 6244, 5894, 5418, 6237, 6358, 6352, 6376 and 6166. Male to female ratio was 1:1.2. Hb A was the most common type of hemoglobin.

The average prevalence of SCD was 1.13%, and the average prevalence of SCT was 13.3%, see Table 1.

Table 1: Sickle Cell Prevalence among Students in Bahrain (1999 - 2008) Year

1999

2000

2001

2002

2003

2004

2005

2006

2007

2008

Disease

SCD

SCT

68

1.20%

785 13.81%

75

1.32%

787

13.82%

68

1.09%

886

14.19%

64

1.09%

838

14.22%

74

1.37%

706

13.03%

78

1.25%

873

14.00%

73

1.15%

805

12.66%

59

0.93%

803

12.64%

67

1.05%

788

12.36%

50

0.81%

789

12.80%

No. of students

5685

5694

6244

5894

5418

6237

6358

6352

6376

6166

 
  
 
     
 

Archive

Title Date Visits

 Levels of pain control

28-09-2011 210

 Public Awareness of Glucose-6- Phosphate Dehydrogenase ( G6PD) Dificiency

11-08-2011 214

 fact about alpha thalassemia

10-08-2011 231

 Prevalence of Abnormal Hemoglobins among Students in Bahrain: A Ten-Year Study

09-03-2011 61

 Beta Thalassemia Frequency in Bahrain: A Ten Year Study

27-09-2010 58

 Public awareness of sickle cell disease in Bahrain

23-09-2010 50

 Premarital genetic counselling A new law in the kingdom of bahrain

23-09-2010 49

 links of several reserch published on Bahrain Medical Bulletin Journal

31-08-2010 52

 The risks and benefits of long-term use of hydroxyurea in sickle cell anemia: A 17.5 year follow-up.

22-06-2010 50

 Frequency of G6PD Deficiency among Bahraini students: A Ten Years Study

01-03-2010 48

الصفحات :1-2-3

الارشيف

العنوان التاريخ الزيارات
 

Public Awareness of Beta Thalassemia in Bahrain

05-04-2012 52
 

THE CHANGING PROFILE OF CONSANGUINITY

01-02-2012 52
 

Levels of pain control

28-09-2011 50
 

The Campaign to control genetic blood diseases in Bahrain.

09-03-2011 58
 

Prevalence of Abnormal Hemoglobins among Students in Bahrain: A Ten-Year Study

09-03-2011 50
 

Beta Thalassemia Frequency in Bahrain: A Ten Year Study

27-09-2010 50
 

Premarital genetic counselling A new law in the kingdom of bahrain

09-03-2011 55
 

Public awareness of sickle cell disease in bahrain

09-03-2011 82
 

روابط لأبحاث مختلفة من مجلة البحرين الطبية

07-07-2010 53
 

Frequency of G6PD Deficiency among Bahraini students: A Ten Years Study

07-07-2010 50

الصفحات :1-2-3-4